Motions of DNA breaks are necessary for the onset of genomic translocations driving the initiation, progression and recurrence of certain cancers. Our preliminary data indicate a transient decrease in chromatin mobility during the DNA damage response (DDR), which may protect genomes from deleterious rearrangements. Here, we propose to combine a novel optical platform (light sheet microscope) and in silico models to investigate the mechanisms regulating chromatin motions during the DDR and to address their functional relevance for genome maintenance.

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